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Hepatitis A Virus Vaccine Inactivated Monograph for

2019-12-23 ensp 0183 ensp Primary immunization consists of a series of 3 doses 186 Each 1-mL dose contains at least 720 units of HAV antigen and 20 mcg of hepatitis B surface antigen HBsAg 186 For primary immunization in most patients give initial dose on a selected date and give second and third doses at 1 and 6 months respectively after initial dose 186...

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Full article Ganoderic acid loaded nano

2019-7-30 ensp 0183 ensp The present work is an effort to explore the possible mechanism of action through five signal molecules such as AKT also known as PKB protein kinase B phosphatidyl inositol-4 5-bisphosphate 3-kinase PI3K nuclear kappa B NF-KB Stat-3 and anti-apoptotic protein B cell lymphoma-2 Bcl-2 in our model of study Kimura et al 2002...

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Biomarker records and mineral compositions of the

2019-8-30 ensp 0183 ensp The evaporites of the Realmonte salt mine Sicily Italy are important archives recording the most extreme conditions of the Messinian Salinity Crisis MSC However geochemical approach on these evaporitic sequences is scarce and little is known on the response of the biological community to drastically elevating salinity In the present work we investigated the depositional environments...

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Developmental studies in fragile X syndrome Journal

2020-5-2 ensp 0183 ensp Fragile X syndrome FXS is the most common single gene cause of autism and intellectual disabilities Humans with FXS exhibit increased anxiety sensory hypersensitivity seizures repetitive behaviors cognitive inflexibility and social behavioral impairments The main purpose of this review is to summarize developmental studies of FXS in humans and in the mouse model the Fmr1 knockout...

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CRUP a comprehensive framework to predict

2019-11-8 ensp 0183 ensp We present the software Condition-specific Regulatory Units Prediction CRUP to infer from epigenetic marks a list of regulatory units consisting of dynamically changing enhancers with their target genes The workflow consists of a novel pre-trained enhancer predictor that can be reliably applied across cell types and species solely based on histone modification ChIP-seq data...

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Targeting metastatic breast cancer with peptide

2019-8-19 ensp 0183 ensp In order to develop a new immunotherapeutic agent targeting metastatic breast cancers we chose to utilize autocatalytic feature of the membrane serine protease Prss14/ST14 a specific prognosis marker for ER negative breast cancer as a target molecule The study was conducted using three mouse breast cancer models 4 T1 and E0771 mouse breast cancer cells into their syngeneic hosts and an...

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Endogenous oxidized DNA bases and APE1 regulate

2020-5-12 ensp 0183 ensp G-quadruplex G4 structures in functionally important genomic regions regulate multiple biological processes in cells This study demonstrates a genome-wide correlation between the occurrence of endogenous oxidative base damage activation of BER and formation of G4 structures Unbiased mapping of AP sites APE1 binding and G4 structures across the genome reveal a distinct...

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